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Related Experiment Video

Updated: Nov 4, 2025

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
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Cyclin E in normal physiology and disease states.

Chen Chu1, Yan Geng1, Yu Zhou2

  • 1Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Genetics, Blavatnik Institute, Harvard Medical School, Boston, MA 02215, USA.

Trends in Cell Biology
|May 30, 2021
PubMed
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Cyclin E, a key cell cycle regulator, drives proliferation and tumor growth. Its elevated activity also promotes therapeutic resistance, highlighting its potential as a drug target.

Keywords:
CDK2cancercell cyclecyclin Ecyclin-dependent kinases

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Area of Science:

  • Cell Biology
  • Molecular Oncology

Background:

  • E-type cyclins (cyclin E) are crucial for cell cycle progression.
  • Cyclin E-CDK2 complexes regulate cell division by phosphorylating key proteins.

Purpose of the Study:

  • To review the diverse functions of cyclin E beyond cell proliferation.
  • To discuss the therapeutic potential of targeting cyclin E and CDK2.

Main Methods:

  • Literature review of existing research on cyclin E.
  • Analysis of cyclin E's role in tumorigenesis and therapeutic resistance.

Main Results:

  • Abnormal cyclin E-CDK2 activity is linked to numerous human cancers.
  • Cyclin E overexpression confers resistance to cancer therapies.
  • Cyclin E regulates various physiological and pathological processes.

Conclusions:

  • Cyclin E has multifaceted roles in cancer and normal physiology.
  • Targeting cyclin E and its kinase partner CDK2 presents a promising therapeutic strategy.