Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Locus-specific proteomics identifies novel regulators of Epstein-Barr virus lytic reactivation.

Journal of virology·2026
Same author

Identification of Epstein-Barr virus BORF2 sequences required for APOBEC3B relocalization.

Journal of virology·2025
Same author

Profiling miRNA changes in Epstein-Barr virus lytic infection identifies a function for BZLF1 in upregulating miRNAs from the DLK1-DIO3 locus.

PLoS pathogens·2025
Same author

The human cytomegalovirus-encoded pUS28 antagonizes CD4+ T cell recognition by targeting CIITA.

eLife·2025
Same author

EBNA1.

Current topics in microbiology and immunology·2025
Same author

Changes in SUMO-modified proteins in Epstein-Barr virus infection identifies reciprocal regulation of TRIM24/28/33 complexes and the lytic switch BZLF1.

PLoS pathogens·2023

Related Experiment Video

Updated: Nov 4, 2025

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
09:14

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Published on: September 28, 2022

4.2K

Epstein-Barr virus: Current questions and challenges.

Lori Frappier1

  • 1Department of Molecular Genetics, University of Toronto, 661 University Ave, Suite 1600, Toronto, ON, M5G 1M1, Canada.

Tumour Virus Research
|May 30, 2021
PubMed
Summary

Epstein-Barr virus (EBV) causes lifelong infections and is linked to cancers and multiple sclerosis. Understanding EBV

Area of Science:

  • Virology
  • Immunology
  • Oncology

Background:

  • Epstein-Barr virus (EBV) establishes lifelong infections in most humans.
  • EBV is associated with various cancers and multiple sclerosis.
  • Mechanisms of EBV-induced disease and rarity of outcomes are not fully understood.

Purpose of the Study:

  • To discuss current hypotheses on EBV's role in disease induction.
  • To explore the significance of lytic protein expression during latent infection.
  • To investigate the potential role of specific EBV variants in disease.

Main Methods:

  • Review of existing literature on EBV pathogenesis.
  • Analysis of the interplay between EBV's lytic and latent infection cycles.
  • Examination of evidence linking specific EBV strains to disease.
Keywords:
Abortive lytic infectionCancer inductionMultiple sclerosisViral variants

More Related Videos

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
09:43

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

9.4K
Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
06:38

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

Published on: November 8, 2011

40.7K

Related Experiment Videos

Last Updated: Nov 4, 2025

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
09:14

Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line

Published on: September 28, 2022

4.2K
An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
09:43

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

9.4K
Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
06:38

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines

Published on: November 8, 2011

40.7K

Main Results:

  • EBV infection is widespread and persistent.
  • EBV is implicated in oncogenesis and neurological disorders.
  • The precise mechanisms of disease induction remain under investigation.

Conclusions:

  • EBV's complex infection cycle contributes to its persistence.
  • Lytic protein expression may be crucial for disease initiation.
  • Specific EBV variants might influence disease susceptibility.