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Theranostics in Neuroblastoma.

Margarida Simao Rafael1, Sarah Cohen-Gogo1, Meredith S Irwin1

  • 1Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, 555 University Ave, Toronto, ON M5G 1X8, Canada.

PET Clinics
|May 31, 2021
PubMed
Summary
This summary is machine-generated.

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Theranostics, combining diagnosis and therapy, utilizes agents like metaiodobenzylguanidine (MIBG) for neuroblastoma. MIBG is valuable for diagnosing, staging, monitoring, and treating this common childhood cancer, especially when relapsed or refractory.

Area of Science:

  • Nuclear medicine
  • Oncology
  • Radiopharmaceutical therapy

Background:

  • Theranostics integrates diagnostic imaging and targeted therapy using radiolabeled molecules.
  • Metaiodobenzylguanidine (MIBG) is a key example, particularly in pediatric oncology.
  • Neuroblastoma is the most common extracranial solid tumor in children.

Purpose of the Study:

  • To highlight the theranostic applications of MIBG in neuroblastoma management.
  • To underscore the role of nuclear medicine in diagnosing and treating neuroblastoma.
  • To discuss the potential of advanced nuclear medicine techniques in neuroblastoma care.

Main Methods:

  • Review of MIBG's diagnostic and therapeutic utility.
  • Discussion of MIBG's application in risk-stratification and response monitoring.
Keywords:
MIBGMIBG therapyNeuroblastomaPET-[(18)F]FDGTheranostics

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  • Exploration of MIBG's role in relapsed/refractory neuroblastoma.

    • Main Results:

    • MIBG serves multiple roles in neuroblastoma: diagnosis, risk-stratification, response monitoring, and therapy.
    • MIBG is particularly effective for treating relapsed or refractory neuroblastoma.
    • Current and emerging nuclear medicine approaches show promise for neuroblastoma.

    Conclusions:

    • MIBG is a versatile theranostic agent for neuroblastoma.
    • Nuclear medicine plays a crucial role in the comprehensive management of neuroblastoma.
    • Advancements in radiopharmaceuticals will further enhance nuclear medicine's impact on neuroblastoma treatment.