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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

473
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
473

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Related Experiment Video

Updated: Nov 4, 2025

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
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Published on: June 10, 2025

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Simple Parameters from Complete Blood Count Predict In-Hospital Mortality in COVID-19.

Mattia Bellan1,2, Danila Azzolina1, Eyal Hayden1,2

  • 1Università del Piemonte Orientale UPO, Novara, Italy.

Disease Markers
|May 31, 2021
PubMed
Summary
This summary is machine-generated.

Complete blood count parameters like red cell distribution width (RDW) and neutrophil-to-lymphocyte (NL) ratio can predict COVID-19 mortality. Higher RDW and NL ratio indicate increased risk, while higher platelet count suggests a protective effect.

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Area of Science:

  • Hematology
  • Infectious Diseases
  • Clinical Pathology

Background:

  • Coronavirus Disease 2019 (COVID-19) presents a wide spectrum of clinical severity.
  • Identifying predictors of poor prognosis is crucial for effective patient management and therapeutic strategies.
  • Complete blood count (CBC) is a readily available laboratory tool.

Purpose of the Study:

  • To evaluate the prognostic value of CBC parameters in hospitalized COVID-19 patients.
  • To identify specific CBC markers that predict in-hospital mortality.

Main Methods:

  • Retrospective analysis of 664 patients hospitalized with COVID-19.
  • Collection of demographic data and complete blood cell counts.
  • Recording of in-hospital outcomes (mortality or discharge).

Main Results:

  • Red cell distribution width (RDW), neutrophil-to-lymphocyte (NL) ratio, and platelet count significantly predicted in-hospital mortality.
  • Age and gender were also strong predictors of mortality.
  • Specific cut-offs identified: NL ratio > 4.68 (OR 3.40), RDW > 13.7% (OR 4.09), and platelet count > 166,000/μL (OR 0.45, protective).

Conclusions:

  • Simple laboratory parameters from CBC can stratify COVID-19 severity.
  • These findings support the use of CBC for guiding clinical decisions in COVID-19 patient monitoring and treatment.
  • RDW, NL ratio, and platelet count offer valuable prognostic information.