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Familial Aggregation in Vitamin D Deficiency Disorder
Leila R Farzin1, Saeed Dastgiri2
1Community and Family Medicine, Tabriz University of Medical Sciences, Tabriz, IRN.
Cureus
|May 31, 2021
Summary
Vitamin D deficiency shows familial aggregation, particularly among siblings and spouses. Early screening is recommended for relatives of diagnosed individuals to enable preventive interventions.
Area of Science:
- Endocrinology
- Genetics
- Public Health
Background:
- Vitamin D deficiency is linked to various diseases, but familial aggregation is understudied.
- Epidemiological data on familial predisposition to vitamin D deficiency is scarce.
Purpose of the Study:
- To investigate the familial aggregation of vitamin D deficiency disorder.
- To assess the role of familial factors in vitamin D deficiency occurrence in Northwest Iran.
Main Methods:
- A cohort of 930 individuals was recruited from a family medicine clinic.
- Vitamin D levels were measured using enzyme-linked immunosorbent assay (ELISA).
- Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated to assess familial aggregation.
Main Results:
- The prevalence of vitamin D deficiency was 62.4% in the studied population.
- Significant familial aggregation was observed among brothers (OR=1.55), sisters (OR=1.24), and spouses (OR=1.18).
- No significant aggregation was found among other relatives like parents or grandparents.
Conclusions:
- Findings suggest a potential familial aggregation of vitamin D deficiency.
- Testing vitamin D levels in siblings and spouses of affected individuals is recommended for early preventive measures.
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