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Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
Published on: August 30, 2014
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Sublingual immunotherapy increases Treg/Th17 ratio in allergic rhinitis
Jiarong Wang1, Liansheng Qiu1, Yimin Chen1
1Department of Otorhinolaryngology, The Second Affiliated Hospital of Fujian Medical University, No. 34 Zhongshan North Road, Quanzhou, Fujiain, 362000, China.
Open Medicine (Warsaw, Poland)
|May 31, 2021
Summary
Sublingual immunotherapy (SLIT) combined with pharmacotherapy effectively treats allergic rhinitis (AR) in children by improving symptoms and modulating regulatory T cells (Tregs) and Th17 cells.
Area of Science:
- Immunology
- Allergy Research
- Pediatric Medicine
Background:
- Limited research exists on sublingual immunotherapy's (SLIT) impact on peripheral regulatory T cells (Tregs) and Th17 cells.
- Allergic rhinitis (AR) affects many children, necessitating effective treatment strategies.
Purpose of the Study:
- To evaluate the efficacy of SLIT in pediatric patients diagnosed with allergic rhinitis.
- To assess the influence of SLIT on the peripheral Tregs/Th17 ratio in children with AR.
Main Methods:
- Retrospective analysis of pediatric AR patients treated between April 2017 and March 2018.
- Comparison of treatment groups: SLIT plus pharmacotherapy versus pharmacotherapy alone.
Main Results:
- The SLIT + pharmacotherapy group showed significant reductions in Visual Analog Scale (VAS) and medication scores compared to baseline.
- In the SLIT group, regulatory T cell (Treg) percentages increased, while Th17 cell percentages decreased significantly.
- The pharmacotherapy-only group experienced a decrease in VAS scores but no significant change in medication scores or immune cell populations.
Conclusions:
- Combined SLIT and pharmacotherapy is an effective treatment for pediatric allergic rhinitis.
- SLIT significantly alters the immune profile by increasing Tregs and decreasing Th17 cells in the peripheral blood of children with AR.
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