Related Experiment Video

Updated: Nov 4, 2025

A Multiplexed Luciferase-based Screening Platform for Interrogating Cancer-associated Signal Transduction in Cultured Cells
10:13

A Multiplexed Luciferase-based Screening Platform for Interrogating Cancer-associated Signal Transduction in Cultured Cells

Published on: July 3, 2013

11.3K

Cross-talk between non-coding RNAs and PI3K/AKT/mTOR pathway in colorectal cancer

Zeinab Moafian1, Abolfazl Maghrouni2, Arash Soltani3

  • 1Protein Chemistry Laboratory (PCL), Department of Biology, College of Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

Molecular Biology Reports
|May 31, 2021
PubMed

Insights

This review explores how non-coding RNAs regulate the PI3K/AKT/mTOR pathway in colorectal cancer (CRC). Understanding these interactions may reveal new diagnostic and therapeutic targets for CRC treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Colorectal cancer (CRC) is a leading cause of cancer mortality worldwide, with metastasis being a primary driver.
  • Current CRC treatments face limitations, necessitating the development of novel therapeutic strategies.
  • The biochemical mechanisms underlying CRC progression remain incompletely understood.

Purpose of the Study:

  • To review the role of non-coding RNAs (ncRNAs) in the development and progression of colorectal cancer.
  • To elucidate the regulatory functions of ncRNAs on the PI3K/AKT/mTOR pathway in CRC.
  • To explore the potential of ncRNAs as diagnostic biomarkers and therapeutic targets for CRC.

Main Methods:

  • Literature review focusing on non-coding RNAs (lncRNAs, miRNAs) and their involvement in CRC.
  • Analysis of the PI3K/AKT/mTOR signaling pathway in the context of CRC.
  • Synthesis of current research on ncRNA-mediated regulation of cancer-related pathways.

Main Results:

  • Non-coding RNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), play significant roles in CRC development and progression.
  • Dysregulation of the PI3K/AKT/mTOR pathway is common in cancers, including CRC.
  • Specific ncRNAs have been identified as key regulators of the PI3K/AKT/mTOR pathway in CRC, influencing tumor growth and metastasis.

Conclusions:

  • Non-coding RNAs are critical regulators of the PI3K/AKT/mTOR pathway in colorectal cancer.
  • Targeting ncRNAs involved in this pathway presents a promising avenue for novel CRC diagnostics and therapeutics.
  • Further research into the precise mechanisms of ncRNAs in CRC is warranted to optimize clinical applications.
Keywords:
AKTColorectal cancer (CRC)LncRNAsMicroRNAsPI3KmTOR pathway

More Related Videos

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants07:38

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants

Published on: June 6, 2025

395
Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies09:29

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Published on: September 30, 2016

14.0K

Related Concept Videos

PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
4.3K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.0K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.8K
MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
6.8K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
7.8K
The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
6.6K