Related Experiment Video
Updated: Nov 4, 2025
Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model
Published on: December 2, 2022
Almond protects the liver in coronary artery disease: A randomized controlled clinical trial
Humaira Jamshed1, Jamshed Arslan2, Fatehali Tipoo Sultan3
1Department of Integrated Sciences and Mathematics, Dhanani School of Science and Engineering, Habib University, Pakistan.
Insights
Consuming almonds, both Pakistani and American varieties, significantly lowered liver enzymes in coronary artery disease patients. This dietary intervention shows almonds are effective for liver protection.
Area of Science:
- Cardiology
- Nutritional Science
- Biochemistry
Background:
- Coronary artery disease (CAD) patients often experience elevated liver enzymes.
- Dietary interventions are explored to manage CAD complications and improve liver health.
Purpose of the Study:
- To compare the impact of Pakistani and American almonds on serum liver enzyme concentrations in CAD patients.
- To assess the efficacy of almond consumption as a liver-protective strategy.
Main Methods:
- A randomized controlled trial involving 150 CAD patients over 12 weeks.
- Intervention groups consumed 10g/day of either Pakistani (PA) or American (AA) almonds.
- Control group (NI) received no almond intervention.
Main Results:
- Dietary almonds significantly reduced serum aspartate transaminase (AST), alanine transaminase (ALT), and gamma-glutamyl transferase (GGT) levels.
- Both PA and AA groups showed significant reductions compared to the NI group (p<0.05).
- Study completion rate was 73.3% (110 participants).
Conclusions:
- A low daily dose of almonds is an effective strategy for liver protection in CAD patients.
- Almonds demonstrate potential therapeutic benefits for liver enzyme management.
- Further research can explore mechanisms and optimal dosages.
Objective:
To compare the effect of Pakistani and American almonds on serum concentration of liver enzymes in coronary artery disease patients.
Methods:
The randomised controlled trial was conducted at the Cardiology Clinics of Aga Khan University Hospital, Karachi, from February to July, 2012, and comprised patients who were randomised into intervention PA and AA groups and the control NI groups. Subjects in the intervention groups were provided Pakistani and American varieties of almonds 10g/day respectively with instructions to soak them overnight, remove the skin and eat them before breakfast for 12 weeks. The control group underwent no intervention. Serum concentrations of aspartate transaminase, Alanine transaminase and gamma-glutamyl transferase were analysed and compared.
Results:
Of the 150 subjects, 110(73.3%) completed the study. Of them, there were 38(34.5%) in PA group, 41(37.3%) in AA, and 31(28.2%) in the NI group. Dietary almonds significantly reduced serum concentrations of aspartate transaminase, alanine transaminase and gamma-glutamyl transferase in the two intervention groups compared to the controls group (p<0.05) at 12-week follow-up.
Conclusions:
A low dose of almonds was found to be an effective strategy to protect the liver.
More Related Videos
07:24Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR
Published on: April 8, 2013
07:03Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
Published on: July 19, 2024
Related Concept Videos
01:26Atherosclerosis III: Management
01:26Coronary Artery Disease IV: Preventive Measures
01:26Coronary Artery Disease II: Pathophysiology
01:30Coronary Artery Disease I: Introduction
01:30Coronary Artery Disease III: Clinical Manifestations
01:24Liver Regeneration
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...