Nrf2 activator PB125® as a carnosic acid-based therapeutic agent against respiratory viral diseases, including...

Area of Science:

• Biochemistry
• Molecular Biology
• Pharmacology

Background:

• Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor regulating metabolic balance and cellular defense.
• Nrf2 activity is crucial for maintaining redox homeostasis, which can be compromised by aging, toxins, and infections.
• Declining Nrf2 levels with age impair the body's ability to manage metabolic dysregulation and increase susceptibility to pathologies.

Purpose of the Study:

• To review the therapeutic potential of Nrf2 activators, focusing on phytochemical compositions like PB125®.
• To examine gene expression patterns associated with pulmonary infections and their modulation by Nrf2.
• To highlight the role of phytochemicals in enhancing Nrf2 activation for normalizing metabolic pathways.

Main Methods:

• Literature review of Nrf2 activators and their mechanisms of action.
• Analysis of gene expression dysregulation in pulmonary infections.
• Examination of phytochemical effects on Nrf2 pathways.

Main Results:

• PB125® demonstrates potent Nrf2 activation and direct cellular actions.
• Nrf2 activation is vital for mitigating metabolic disruption caused by various stressors.
• Phytochemicals can therapeutically increase Nrf2 levels, counteracting age-related decline and infection susceptibility.

Conclusions:

• Nrf2 activators, particularly phytochemicals, hold significant therapeutic promise for metabolic and infectious diseases.
• Targeting Nrf2 pathways offers a strategy to address age-related decline in metabolic regulation.
• Judicious use of phytochemicals can restore redox balance and normalize gene expression during pathological conditions.