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Multimodal guided wave inversion for arterial stiffness: methodology and validation in phantoms
Tuhin Roy1, Matthew Urban2,3, Yingzheng Xu4
1Department of Civil Engineering, North Carolina State University, Raleigh, NC, United States of America.
Physics in Medicine and Biology
|June 1, 2021
Summary
This study introduces an advanced guided wave inversion (GWI) method to accurately measure arterial stiffness. The new technique enhances accuracy in estimating arterial modulus and wall thickness, crucial for cardiovascular disease assessment.
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
- Medical Imaging
Background:
- Arterial stiffness is a key indicator of cardiovascular disease risk.
- Shear wave elastography (SWE) with guided wave inversion (GWI) estimates arterial stiffness.
- Existing GWI methods require refinement for improved accuracy.
Purpose of the Study:
- To develop and validate a novel GWI approach for precise arterial stiffness measurement.
- To enhance the accuracy of modulus and wall thickness estimation in arteries.
- To create a computationally efficient GWI method.
Main Methods:
- Refined signal processing for accurate experimental dispersion curves.
- Developed an efficient forward model for cylindrical waveguides.
- Implemented a multimodal GWI optimization framework.
Main Results:
- Validated the GWI approach using extensive experimental data from rubber tube phantoms.
- Achieved accurate simultaneous estimation of arterial modulus and wall thickness.
- Demonstrated modulus estimation with less than 4% error in 70% of experiments.
Conclusions:
- The novel GWI approach accurately estimates arterial stiffness, modulus, and wall thickness.
- Incorporating wall thickness information improves modulus estimation.
- The method is rapid, efficient, and suitable for clinical applications.
