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Updated: Nov 3, 2025

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
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[Diagnosis and treatment of HIV-associated lymphoma: Update 202]

Marcus Hentrich1

  • 1Rotkreuzklinikum München, Abteilung für Innere Medizin III - Hämatologie/Onkologie, München.

Deutsche Medizinische Wochenschrift (1946)
|June 1, 2021
PubMed

The risk of malignant lymphomas is markedly increased in HIV-infected persons even in the era of effective combination antiretroviral therapy. Major risk factors are the depth of CD4-cell nadir and HIV viremia. R-CHOP remains treatment of choice for diffuse large B-cell lymphoma. In HIV-Burkitt lymphoma CODOX-M/IVAC proved superior to EPOCH in a large retrospective study. Standard treatment for plasmablastic or primary effusion lymphoma has not yet been defined. Favourable results have been reported with a stage adapted treatment for HIV-Hodgkin lymphoma. Patients with relapsed/refractory HIV-lymphoma should undergo autologous stem cell transplantation if indicated. Successful anti-CD19 CAR T-cell therapy was also reported in HIV-infected patients with refractory B-cell lymphoma.

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