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Long Non-Coding RNAs as Functional Codes for Oral Cancer: Translational Potential, Progress and Promises
Cing-Syuan Lei1, Hsing-Jien Kung1,2,3,4,5, Jing-Wen Shih1,2,5,6
1Ph.D. Program for Cancer Molecular Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei 11031, Taiwan.
International Journal of Molecular Sciences
|June 2, 2021
Summary
Long non-coding RNAs (lncRNAs) show promise as biomarkers for early oral cancer detection and potential therapeutic targets. Research highlights their crucial roles in oral cancer progression and signaling pathways, offering new avenues for treatment.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Oral cancer remains a significant global health challenge with poor prognosis often due to late diagnosis.
- Effective biomarkers for early detection and novel therapeutic strategies are urgently needed.
Purpose of the Study:
- To summarize recent advances in understanding oral cancer-associated long non-coding RNAs (lncRNAs).
- To explore the expression, involvement, and clinical potential of lncRNAs in oral cancer.
- To focus on lncRNA-mediated regulation of oncogenic signaling and oral malignant progression.
Main Methods:
- Literature review of recent studies on lncRNAs in oral cancer.
- Analysis of lncRNA expression patterns and their correlation with tumorigenesis and prognosis.
- Investigation of lncRNA roles in key oncogenic signaling pathways.
Main Results:
- An increasing number of lncRNAs have been identified and linked to oral cancer development and progression.
- lncRNAs play pivotal roles in regulating gene expression within oncogenic signaling cascades.
- Specific lncRNAs demonstrate potential as diagnostic biomarkers and therapeutic targets.
Conclusions:
- lncRNAs are emerging as critical regulators in oral cancer.
- Further research into lncRNA functions and clinical applications is warranted for improved oral cancer management.
- lncRNAs hold promise as future biomarkers and therapeutic targets for oral cancer.
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