Dual-Retarder Mueller Polarimetry System for Extraction of Optical Properties of Serum Albumin Protein Media

A dual liquid-crystal variable retarder Mueller polarimetry system incorporating a gold-based surface plasmon resonance prism coupler was proposed for extracting the optical properties of serum albumin protein media in the reflectance configuration. The feasibility of the proposed system was demonstrated by measuring the circular dichroism and circular birefringence properties of glucose tissue phantom solutions with different albumin concentrations. The results showed that the circular dichroism increased with albumin concentration, while the optical rotation angle increased with glucose concentration. Both properties reduced over time as a result of the protein glycation effect, which led to a gradual reduction in the glucose content of the sample.