Application of microRNA in Human Osteoporosis and Fragility Fracture: A Systemic Review of Literatures
Yen-Zung Wu1,2, Hsuan-Ti Huang1,2,3,4,5,6, Tsung-Lin Cheng1,3,4,7
1Orthopaedic Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.
Abstract:
MicroRNAs (miRNAs) could serve as ideal entry points to the deregulated pathways in osteoporosis due to their relatively simple upstream and downstream relationships with other molecules in the signaling cascades. Our study aimed to give a comprehensive review of the already identified miRNAs in osteoporosis from human blood samples and provide useful information for their clinical application. A systematic literature search for relevant studies was conducted in the Pubmed database from inception to December 2020. We set two essential inclusion criteria: human blood sampling and design of controlled studies. We sorted the results of analysis on human blood samples according to the study settings and compiled the most promising miRNAs with analyzed diagnostic values. Furthermore, in vitro and in vivo evidence for the mechanisms of the identified miRNAs was also illustrated. Based on both diagnostic value and evidence of mechanism from in vitro and in vivo experiments, miR-23b-3p, miR-140-3p, miR-300, miR-155-5p, miR-208a-3p, and miR-637 were preferred candidates in diagnostic panels and as therapeutic agents. Further studies are needed to build sound foundations for the clinical usage of miRNAs in osteoporosis.
Insights
This review identifies key microRNAs (miRNAs) in blood for diagnosing osteoporosis. Several miRNAs show promise as diagnostic markers and potential therapeutic agents for osteoporosis treatment.
Area of Science:
- Biochemistry
- Molecular Biology
- Genetics
Background:
- Osteoporosis involves complex deregulated pathways.
- MicroRNAs (miRNAs) offer a simplified approach to understanding these pathways.
- Identifying specific miRNAs in blood can aid osteoporosis diagnosis and treatment.
Purpose of the Study:
- To comprehensively review identified miRNAs in human blood related to osteoporosis.
- To assess their diagnostic value and potential for clinical application.
- To explore the mechanisms of action for promising miRNAs.
Main Methods:
- Systematic literature search of the PubMed database (inception to December 2020).
- Inclusion criteria: human blood samples and controlled study designs.
- Analysis of diagnostic values and in vitro/in vivo mechanistic evidence.
Main Results:
- Identified and compiled promising miRNAs from human blood samples.
- Evaluated diagnostic values and mechanistic evidence for selected miRNAs.
- Highlighted miR-23b-3p, miR-140-3p, miR-300, miR-155-5p, miR-208a-3p, and miR-637 as top candidates.
Conclusions:
- Selected miRNAs demonstrate significant diagnostic potential for osteoporosis.
- These miRNAs are also promising candidates for therapeutic interventions.
- Further research is required to establish clinical utility for osteoporosis management.
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