Related Experiment Video
Updated: Nov 3, 2025

10:45
Deep Dermal Injection As a Model of Candida albicans Skin Infection for Histological Analyses
Published on: June 13, 2018
11.0K
Adnexotropic Variants of the Interface Dermatitides: A Review.
Carla Stephan1, Ossama Abbas1, Jag Bhawan2
1Department of Dermatology, American University of Beirut, Beirut 11-0236, Lebanon.
Dermatopathology (Basel, Switzerland)
|June 2, 2021
Summary
Interface dermatitides can affect skin adnexa, including hair follicles and eccrine glands. Recognizing these adnexotropic patterns aids dermatopathologists in accurate diagnosis, distinguishing them from conditions like mycosis fungoides.
Area of Science:
- Dermatopathology
- Cutaneous Medicine
- Histopathology
Background:
- Interface dermatitides are diverse skin conditions.
- Some present with adnexal (hair follicle, eccrine gland) involvement.
- Histopathological findings reveal adnexal changes in certain cases.
Purpose of the Study:
- To review and describe adnexotropic presentations of interface dermatitides.
- To highlight the importance of recognizing adnexal involvement in diagnosis.
- To help differentiate these conditions from other skin diseases.
Main Methods:
- Literature review of interface dermatitides with adnexal predilection.
- Analysis of histopathological features related to adnexal structures.
- Synthesis of clinical variants and their adnexal involvement patterns.
Main Results:
- Interface dermatitides frequently exhibit adnexal involvement.
- Specific clinical variants show a predilection for adnexal structures.
- Histopathology confirms hair follicle and eccrine gland changes.
Conclusions:
- Adnexal involvement is a key feature in certain interface dermatitides.
- Awareness of adnexotropism aids accurate dermatopathological diagnosis.
- This recognition helps avoid misdiagnosis, particularly with mycosis fungoides.
Keywords:
folliculotropicgraft versus host diseaseinterface dermatitislichen nitiduslichen planuslichen sclerosuslichen striatusmycosis fungoidessyringotropicMore Related Videos
Related Concept Videos
Skin Diseases and Disorders
4.5K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
4.5K
Adherens Junctions
5.4K
Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types – adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
Adherens Junctions are Dynamic
5.4K
Desmosomes
6.3K
The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein...
6.3K
Diversity of Protists II
576
Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
576
Protein-protein Interfaces
14.1K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
14.1K
Accessory Structures of the Skin: Sebaceous Glands
3.0K
A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
3.0K

