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The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
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Antimicrobial Polymer-Based Assemblies: A Review.

Ana Maria Carmona-Ribeiro1, Péricles Marques Araújo1

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This summary is machine-generated.

Antimicrobial supramolecular assemblies (ASAs) offer promising alternatives to combat drug-resistant microbes. Polymer-based antimicrobial assemblies show advantages over peptide-based ones due to cost, stability, and efficacy.

Keywords:
ESKAPE pathogensMRSAantibiofilm and thromboresistant activitycationic peptides and polymershydrophobic–hydrophilic balancemechanism of cell lysismultidrug−resistant microbesquaternized biopolymersstructure–function relationship

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Area of Science:

  • Biomaterials Science
  • Microbiology
  • Polymer Chemistry

Background:

  • Antimicrobial supramolecular assemblies (ASAs) are crucial in biomedical applications for combating microbial resistance.
  • Antimicrobial peptides (AMPs) and polymers (APs) are key components of ASAs, offering distinct advantages and delivery methods.
  • Existing drug resistance necessitates novel antimicrobial strategies like ASAs.

Purpose of the Study:

  • To review recent advancements in polymer-based antimicrobial assemblies.
  • To compare the efficacy and characteristics of antimicrobial peptides (AMPs) and antimicrobial polymers (APs).
  • To highlight the potential of ASAs in overcoming microbial resistance.

Main Methods:

  • Literature review of recent research on ASAs, focusing on polymer-based systems.
  • Analysis of delivery mechanisms and applications of ASAs.
  • Comparative assessment of AMPs and APs based on synthesis, stability, and antimicrobial action.

Main Results:

  • ASAs, including AMPs and APs, demonstrate effective antimicrobial activity with acceptable toxicity.
  • Antimicrobial polymers (APs) offer advantages in cost-effective synthesis, chemical stability, and enhanced microbial adsorption compared to AMPs.
  • Various carriers like nanoparticles, hydrogels, and liposomes are utilized for ASA delivery.

Conclusions:

  • Polymer-based antimicrobial assemblies represent a significant advancement in antimicrobial strategies.
  • APs present a more viable and advantageous alternative to AMPs for developing robust antimicrobial formulations.
  • ASAs hold considerable promise for future therapeutic applications against resistant microbial infections.