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Cyclodextrin Monomers and Polymers for Drug Activity Enhancement
Adrián Matencio1, Gjylije Hoti1, Yousef Khazaei Monfared1
1Dip. Di Chimica, Università di Torino, Via P. Giuria 7, 10125 Torino, Italy.
Polymers
|June 2, 2021
Summary
Cyclodextrins (CDs) and their polymers enhance drug activity by forming complexes. This review explores their performance as activity enhancers across various therapeutic areas.
Area of Science:
- Pharmacology
- Materials Science
Background:
- Cyclodextrins (CDs) and cyclodextrin-based polymers are recognized for their complexation capabilities.
- These agents can increase drug solubility and improve drug delivery.
- Drug activity can be enhanced not solely by increased dosage but also by complexation with CDs.
Purpose of the Study:
- To review the performance of CDs and CD-based polymers as drug activity enhancers.
- To summarize findings on how drug complexation influences therapeutic efficacy.
Main Methods:
- Literature review of numerous studies on cyclodextrins and drug activity.
- Categorization of effects based on therapeutic applications.
Main Results:
- Drug complexation with CDs often leads to increased drug activity.
- CDs and their polymers demonstrate efficacy as enhancers in various drug formulations.
Conclusions:
- Cyclodextrins and cyclodextrin-based polymers are effective agents for enhancing drug activity.
- Their role extends to improving therapeutic outcomes in diverse medical fields.
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