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Bioactive Co(II), Ni(II), and Cu(II) Complexes Containing a Tridentate Sulfathiazole-Based (ONN) Schiff Base.
Aurora Reiss1, Nicoleta Cioateră1, Aurelian Dobrițescu1
1Department of Chemistry, Faculty of Sciences, University of Craiova, 13 AI Cuza Street, 200585 Craiova, Romania.
Molecules (Basel, Switzerland)
|June 2, 2021
Summary
New Schiff base metal complexes of cobalt, nickel, and copper exhibit enhanced antibacterial activity. These synthesized complexes show improved efficacy against bacterial strains compared to the original Schiff base ligand.
Area of Science:
- Coordination Chemistry
- Materials Science
- Medicinal Chemistry
Background:
- Schiff bases derived from sulfathiazole and salicylaldehyde are versatile ligands.
- Metal complexes often display unique biological and material properties.
Purpose of the Study:
- Synthesize and characterize novel Co(II), Ni(II), and Cu(II) complexes with a Schiff base ligand.
- Evaluate the antibacterial activity of the synthesized complexes.
Main Methods:
- Schiff base ligand synthesis via condensation.
- Complex synthesis and characterization (elemental analysis, spectroscopy, thermal analysis, XRD, SEM, EDS).
- Antibacterial screening against E. coli, P. aeruginosa, S. aureus, and B. subtilis.
Main Results:
- Tridentate coordination of the Schiff base ligand (N2O donor set).
- Formation of [ML2]·nH2O complexes with octahedral geometries.
- XRD confirmed monoclinic polycrystalline structure; SEM showed micrometric agglomerates.
- Metal complexes demonstrated superior antibacterial activity compared to the free ligand.
Conclusions:
- The synthesized Schiff base metal complexes possess defined structural and morphological characteristics.
- The metal complexes exhibit enhanced antibacterial properties, suggesting potential therapeutic applications.
Keywords:
Co(II), Ni(II) and Cu(II) complexesSchiff baseantibacterial activitysulfathiazolethermal behaviorMore Related Videos
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