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Platelet-Derived Growth Factor-Modulated Guided Tissue Regeneration with a Bioresorbable Membrane in Class III
Dietmar Weng1, Lina Stapf1, Matthias Kern1
1Department of Prosthodontics, Propaedeutics and Dental Materials, School of Dentistry, Christian-Albrechts University, Arnold-Heller-Str. 16, 24105 Kiel, Germany.
Materials (Basel, Switzerland)
|June 2, 2021
Summary
Guided tissue regeneration (GTR) with bone mineral, with or without platelet-derived growth factor (PDGF), did not improve class III furcation defects in monkeys. Negative controls showed better bone regeneration, suggesting PDGF did not enhance GTR outcomes.
Area of Science:
- Periodontology
- Regenerative Dentistry
- Oral Surgery
Background:
- Class III furcation defects present significant challenges in periodontal regeneration.
- Guided tissue regeneration (GTR) aims to restore lost periodontal tissues.
- Platelet-derived growth factor (PDGF) is investigated for its potential to enhance bone regeneration.
Purpose of the Study:
- To histometrically evaluate guided tissue regeneration (GTR) using a bioresorbable membrane and bone mineral, with or without PDGF, in monkey class III furcation defects.
- To compare the regenerative outcomes between GTR with PDGF and GTR alone.
- To assess the influence of two different class III furcation defect types on regenerative success.
Main Methods:
- Class III furcation defects (small keyhole and horizontal) were created in cynomolgus monkey molars and allowed to heal for 5 months.
- Defects were treated with GTR (membrane + bone mineral), PDGF (GTR + PDGF), or negative control (flap reposition only).
- Histometric analysis of regenerated tissues (bone, cementum, connective tissue, epithelium) was performed after 7 months of healing.
Main Results:
- Bone regeneration ranged from 23-35% in the GTR and PDGF groups.
- No significant differences in bone, cementum, connective tissue, or epithelium formation were observed between the GTR and PDGF groups.
- The negative control group exhibited superior bone regeneration compared to both treatment groups.
- The type of class III defect did not impact the regenerative outcome.
Conclusions:
- Platelet-derived growth factor (PDGF) did not enhance histologic regeneration in class III furcation defects when combined with GTR and bone mineral in this monkey model.
- Guided tissue regeneration (GTR) with bone mineral alone did not yield superior results compared to the negative control.
- Marginal membrane exposure during early healing may have negatively impacted the outcomes of the GTR and PDGF treatments.
