Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Early Endosome: Endocytosis of Transferrin01:28

The Early Endosome: Endocytosis of Transferrin

4.0K
Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
4.0K
Necrosis01:16

Necrosis

5.2K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
5.2K
Overview of Fatty Acid Metabolism01:28

Overview of Fatty Acid Metabolism

32.7K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
32.7K
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

362
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
362
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

1.5K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
1.5K
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

1.7K
Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Clinical Investigation of Hypoxic Red Blood Cell Administration in Patients with Transfusion-Dependent Hematological Malignancies and Burns.

Journal of blood medicine·2026
Same author

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·2026
Same author

Relapse of Acute Myeloid Leukemia With Concomitant Systemic Mastocytosis Five Years Post Allogenic Hematopoietic Stem Cell Transplantation.

Case reports in hematology·2026
Same author

Correction: Solberg, A.; Reikvam, H. Iron Status and Physical Performance in Athletes. <i>Life</i> 2023, <i>13</i>, 2007.

Life (Basel, Switzerland)·2026
Same author

NUP214 in Acute Myeloid Leukemia.

Cells·2025
Same author

Three-Month Posttransplant Lipidomic Profile Reflects Acute GVHD but Not Chronic GVHD Risk in Allogeneic Stem Cell Recipients.

European journal of haematology·2025

Related Experiment Video

Updated: Nov 3, 2025

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts
09:21

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts

Published on: February 23, 2024

1.1K

Hyperferritinemia-A Clinical Overview.

Miriam Sandnes1, Rune J Ulvik1, Marta Vorland2

  • 1Department of Clinical Science, University of Bergen, 5021 Bergen, Norway.

Journal of Clinical Medicine
|June 2, 2021
PubMed
Summary
This summary is machine-generated.

High ferritin levels are common but often non-specific, frequently indicating inflammation rather than iron overload. This review clarifies hyperferritinemia diagnosis and management, differentiating iron overload from reactive ferritin increases.

Keywords:
ferritinhemochromatosisinflammationiron

More Related Videos

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
04:01

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

1.4K
Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining
07:32

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Published on: May 23, 2025

629

Related Experiment Videos

Last Updated: Nov 3, 2025

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts
09:21

Ferritinophagy: Assessing the Selective Degradation of Iron by Autophagy in Human Fibroblasts

Published on: February 23, 2024

1.1K
Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
04:01

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

1.4K
Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining
07:32

Assessing Iron Deposition in the Brains of 5xFAD Mice by Perls'/DAB Staining

Published on: May 23, 2025

629

Area of Science:

  • Clinical Biochemistry
  • Internal Medicine
  • Hematology

Background:

  • Ferritin testing is a common laboratory investigation.
  • Low ferritin indicates iron deficiency, but high ferritin (hyperferritinemia) is often non-specific.
  • Hyperferritinemia is frequently overlooked in general practice and can be due to iron overload or reactive increases.

Purpose of the Study:

  • To review the biology, etiology, and epidemiology of hyperferritinemia.
  • To differentiate iron overload from reactive hyperferritinemia.
  • To propose a diagnostic and management algorithm for hyperferritinemia.

Main Methods:

  • Literature review based on authors' experience and international guidelines.
  • Analysis of the diagnostic challenges in hyperferritinemia.
  • Development of a proposed algorithm for workup and management.

Main Results:

  • Hyperferritinemia is a non-specific finding in 10% of cases related to iron overload.
  • The majority of hyperferritinemia cases result from acute phase reactions or underlying conditions.
  • Differentiating iron overload from reactive increases is essential but complex.

Conclusions:

  • A systematic approach is needed to manage hyperferritinemia.
  • The proposed algorithm aids in the diagnostic workup of hyperferritinemia.
  • Understanding the etiology is key to appropriate management of iron overload.