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DNMT3A Mutation-Induced CDK1 Overexpression Promotes Leukemogenesis by Modulating the Interaction between EZH2 and

Ying Yang1, Yujun Dai1, Xuejiao Yang1

  • 1Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Biomolecules
|June 2, 2021
PubMed
Summary

Cyclin-dependent kinase 1 (CDK1) overexpression promotes acute myeloid leukemia (AML) with DNMT3A mutations. Inhibiting CDK1 may offer a new therapeutic strategy for this aggressive cancer.

Keywords:
CDK1DNA methyltransferase 3Aacute myeloid leukemiamutationtargeted therapy

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