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Inflammation

Inflammation

Atherosclerosis I: Introduction

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...

Coronary Artery Disease I: Introduction

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...

Peripheral Artery Disease I: Introduction

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...

Atherosclerosis III: Management

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...

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Related Experiment Video

Updated: Nov 3, 2025

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

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Published on: May 6, 2014

Inflammation and Atherosclerosis.

¹Laboratory of Inflammation Biology, La Jolla Institute for Immunology, 9420 Athena Circle Drive, La Jolla, San Diego, CA 92037, USA.

|June 2, 2021

Summary

Inflammation plays a critical role in atherosclerosis, the hardening of arteries. This special issue covers basic science, translational research, and clinical trials on inflammatory mechanisms in cardiovascular disease.

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Area of Science:

Cardiovascular Science
Immunology
Translational Medicine

Background:

Atherosclerosis is a chronic inflammatory disease.
Inflammation is a key driver of atherosclerotic plaque development and progression.
Understanding inflammatory pathways is crucial for developing new treatments.

Discussion:

This special issue explores the multifaceted role of inflammation in atherosclerosis.
It bridges basic science discoveries with clinical applications.
The content covers mechanistic insights from animal models to human clinical trial outcomes.

Key Insights:

Inflammation is central to all stages of atherosclerosis.
Targeting specific inflammatory pathways holds therapeutic potential.
A comprehensive understanding requires integrating diverse research approaches.

Outlook:

Future research should focus on precise targeting of inflammatory mediators.
Clinical trials will continue to evaluate anti-inflammatory strategies.
Personalized medicine approaches may leverage inflammatory profiles for atherosclerosis treatment.