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Related Concept Videos

Maintenance of the ES Cell State01:14

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The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Related Experiment Video

Updated: Nov 3, 2025

Oct4GiP Reporter Assay to Study Genes that Regulate Mouse Embryonic Stem Cell Maintenance and Self-renewal
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Long Non-Coding RNA MEG3 in Cellular Stemness.

Pei-Fang Hsieh1,2, Cheng-Chia Yu3,4,5, Pei-Ming Chu6

  • 1Department of Urology, E-Da Hospital, Kaohsiung 82445, Taiwan.

International Journal of Molecular Sciences
|June 2, 2021
PubMed
Summary
This summary is machine-generated.

Long non-coding RNA MEG3 (lncRNA MEG3) plays a key role in stemness and differentiation. This review explores how lncRNA MEG3 regulates pluripotency, multi-lineage differentiation, and cancer progression.

Keywords:
cancer stem cellsembryonic stem cellslong non-coding RNA MEG3mesenchymal stem cells

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Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Long non-coding RNAs (lncRNAs) are crucial regulators of gene expression across multiple cellular levels.
  • The lncRNA MEG3 has emerged as a significant modulator of cellular stemness and differentiation pathways.

Purpose of the Study:

  • To review the molecular mechanisms of lncRNA MEG3 in regulating stemness, differentiation, and cancer progression.
  • To provide an overview of MEG3's functional versatility in various stem cell types and cancer stem cells.

Main Methods:

  • Literature review focusing on molecular mechanisms of lncRNA MEG3.
  • Analysis of studies investigating MEG3's role in pluripotency, differentiation, and cancer stemness.

Main Results:

  • lncRNA MEG3 acts as a signal, scaffold, guide, and decoy in cellular processes.
  • MEG3 influences multi-lineage differentiation and cancer progression.
  • The role of MEG3 in diverse stem cells and cancer stem cells is highlighted.

Conclusions:

  • lncRNA MEG3 exhibits remarkable functional versatility in modulating stemness and differentiation.
  • Understanding MEG3's mechanisms is vital for potential therapeutic strategies in regenerative medicine and oncology.