Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Topology optimization for link mechanism synthesis based on multi-layered generalized continuum model.

Proceedings of the Japan Academy. Series B, Physical and biological sciences·2026
Same author

In vitro and in vivo models for androgenetic alopecia drug development.

Disease models & mechanisms·2026
Same author

A conserved mechanism for stabilization of viral innate immune antagonists via interaction with Elongin BC.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Accelerated directional growth of seaweed-like iron oxide branches driven by localized electric fields of gold nanoparticles in liquid.

Nature communications·2026
Same author

Initiator-Free Recyclable Anthracene-Based Photocurable Resin Enabling Sustainable 3D Printing via Single- and Two-Photon Stereolithography.

ACS omega·2026
Same author

Phototunable Gelatin-Based Hydrogels as Cell Scaffolds for Modulating Cell Adhesion on Hydrogel Surfaces.

ACS applied bio materials·2026

Related Experiment Video

Updated: Nov 3, 2025

Rod-based Fabrication of Customizable Soft Robotic Pneumatic Gripper Devices for Delicate Tissue Manipulation
07:49

Rod-based Fabrication of Customizable Soft Robotic Pneumatic Gripper Devices for Delicate Tissue Manipulation

Published on: August 2, 2016

9.0K

3D-Printed Micro-Tweezers with a Compliant Mechanism Designed Using Topology Optimization.

Yukihito Moritoki1, Taichi Furukawa2, Jinyi Sun1

  • 1Graduate School of Engineering Science, Yokohama National University, 79-5 Tokiwadai, Hodogaya-ku, Yokohama 240-8501, Japan.

Micromachines
|June 2, 2021
PubMed
Summary

Researchers developed novel micro-tweezers using microstereolithography and topology optimization for precise manipulation of organoids. This technology advances regenerative medicine by enabling delicate handling of microscopic biological samples.

Keywords:
3D printingcompliant mechanismmicro-manipulatormicro-tweezersmicrostereolithographytopology optimization

More Related Videos

Three-dimensional Printing of Thermoplastic Materials to Create Automated Syringe Pumps with Feedback Control for Microfluidic Applications
09:08

Three-dimensional Printing of Thermoplastic Materials to Create Automated Syringe Pumps with Feedback Control for Microfluidic Applications

Published on: August 30, 2018

12.7K
Design and Implementation of a Bespoke Robotic Manipulator for Extra-corporeal Ultrasound
07:41

Design and Implementation of a Bespoke Robotic Manipulator for Extra-corporeal Ultrasound

Published on: January 7, 2019

9.4K

Related Experiment Videos

Last Updated: Nov 3, 2025

Rod-based Fabrication of Customizable Soft Robotic Pneumatic Gripper Devices for Delicate Tissue Manipulation
07:49

Rod-based Fabrication of Customizable Soft Robotic Pneumatic Gripper Devices for Delicate Tissue Manipulation

Published on: August 2, 2016

9.0K
Three-dimensional Printing of Thermoplastic Materials to Create Automated Syringe Pumps with Feedback Control for Microfluidic Applications
09:08

Three-dimensional Printing of Thermoplastic Materials to Create Automated Syringe Pumps with Feedback Control for Microfluidic Applications

Published on: August 30, 2018

12.7K
Design and Implementation of a Bespoke Robotic Manipulator for Extra-corporeal Ultrasound
07:41

Design and Implementation of a Bespoke Robotic Manipulator for Extra-corporeal Ultrasound

Published on: January 7, 2019

9.4K

Area of Science:

  • Biotechnology
  • Mechanical Engineering
  • Regenerative Medicine

Background:

  • Advancements in regenerative medicine and tissue engineering necessitate sophisticated handling technologies for microscopic biological samples like cells and spheroids.
  • Current methods may lack the precision or adaptability required for manipulating delicate biological structures.

Purpose of the Study:

  • To develop and validate micro-tweezers with a compliant mechanism for manipulating organoids.
  • To integrate high-resolution microstereolithography and topology optimization for fabricating these micro-manipulation tools.

Main Methods:

  • Fabrication of micro-tweezers using high-resolution microstereolithography with a blue laser.
  • Shape optimization of the micro-tweezers via topology optimization.
  • Development of an actuation system with a linear motor stage and force control for operating the micro-tweezers.
  • Analytical and experimental examination of micro-tweezer deformation and displacement characteristics.

Main Results:

  • The topology-optimized micro-tweezers exhibited displacement proportional to the applied load.
  • The achieved displacement was sufficient for grasping biological samples with diameters in the hundreds of micrometers.
  • Successful experimental manipulation of a 360 µm diameter organoid was demonstrated.

Conclusions:

  • The combination of microstereolithography and topology optimization provides a viable method for fabricating effective micro-tweezers.
  • These micro-tweezers show significant potential for handling various microscopic biological samples in regenerative medicine and tissue engineering applications.