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Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease
Jesús Burillo1,2,3, Patricia Marqués1,3, Beatriz Jiménez1,2,3
1Department of Biochemistry, Complutense University, 28040 Madrid, Spain.
Abstract:
Type 2 diabetes mellitus is a progressive disease that is characterized by the appearance of insulin resistance. The term insulin resistance is very wide and could affect different proteins involved in insulin signaling, as well as other mechanisms. In this review, we have analyzed the main molecular mechanisms that could be involved in the connection between type 2 diabetes and neurodegeneration, in general, and more specifically with the appearance of Alzheimer's disease. We have studied, in more detail, the different processes involved, such as inflammation, endoplasmic reticulum stress, autophagy, and mitochondrial dysfunction.
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