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Association between Proton Pump Inhibitors and Hearing Impairment: A Nested Case-Control Study.
So Young Kim1, Chang Ho Lee1, Chanyang Min2,3
1Department of Otorhinolaryngology-Head & Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam 13496, Korea.
Current Issues in Molecular Biology
|June 2, 2021
Summary
Proton pump inhibitor (PPI) use is linked to a higher risk of hearing impairment. Even short-term use showed increased odds, with longer duration associated with greater risk in adults.
Area of Science:
- Otolaryngology
- Gastroenterology
- Pharmacology
Background:
- Proton pump inhibitors (PPIs) are widely prescribed for acid-related gastrointestinal disorders.
- Potential adverse effects of long-term PPI use are a growing concern.
- The association between PPIs and hearing impairment requires further investigation.
Purpose of the Study:
- To investigate the association between previous proton pump inhibitor (PPI) use and the incidence of hearing impairment.
- To analyze the dose-response relationship between PPI duration and hearing impairment risk.
Main Methods:
- A population-based cohort study using the Korean National Health Insurance Service-Health Screening Cohort (≥40 years old).
- Matched analysis of 6,626 hearing-impaired patients and 508,240 controls based on demographics and index date.
- Conditional logistic regression analysis of PPI prescription data for 2 years prior to diagnosis.
Main Results:
- PPI use for 30-365 days was associated with a 1.65-fold increased odds of hearing impairment (95% CI: 1.47-1.86).
- PPI use for ≥365 days showed a 1.52-fold increased odds of hearing impairment (95% CI: 1.35-1.72, p < 0.001).
- Positive associations were observed across all age/sex subgroups and were more pronounced in severe hearing impairment cases.
Conclusions:
- Previous proton pump inhibitor (PPI) use is associated with an increased rate of hearing impairment.
- The findings suggest a potential risk of hearing loss with PPI medication, warranting further research into underlying mechanisms.
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