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Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

Thiazole Ring-A Biologically Active Scaffold.

Anthi Petrou¹, Maria Fesatidou¹, Athina Geronikaki¹

¹School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

Molecules (Basel, Switzerland)

|June 2, 2021

Summary

Thiazole derivatives show diverse biological activities, making them valuable in drug discovery. This review covers recent research on their synthesis and applications, highlighting their pharmaceutical importance.

Keywords:

HIV anti-inflammatory anticonvulsant antimicrobial antioxidant antiviral carbonic anhydise neglected thiazoles tuberculosis

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Area of Science:

Medicinal Chemistry
Organic Chemistry

Background:

The thiazole ring is a crucial pharmacophore with broad pharmaceutical applications.
Thiazole derivatives exhibit a wide spectrum of biological activities, including antioxidant, antimicrobial, and anticancer properties.
This scaffold is present in numerous FDA-approved and experimental drugs.

Purpose of the Study:

To review and synthesize recent literature on the biological activities of thiazole derivatives.
Focus on research published from 2015 to the present.

Main Methods:

A comprehensive literature survey was conducted.
Articles were critically analyzed and organized based on synthesis and biological activities.

Main Results:

Approximately 124 research articles published in the last five years were identified and reviewed.
The findings cover the synthesis and diverse biological activities of thiazole derivatives.

Conclusions:

Thiazole derivatives continue to be a significant area of research in medicinal chemistry.
Recent literature underscores their potential for developing novel therapeutic agents.