Thiazole Ring-A Biologically Active Scaffold
Anthi Petrou1, Maria Fesatidou1, Athina Geronikaki1
1School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Background:
Thiazole is a good pharmacophore nucleus due to its various pharmaceutical applications. Its derivatives have a wide range of biological activities such as antioxidant, analgesic, and antimicrobial including antibacterial, antifungal, antimalarial, anticancer, antiallergic, antihypertensive, anti-inflammatory, and antipsychotic. Indeed, the thiazole scaffold is contained in more than 18 FDA-approved drugs as well as in numerous experimental drugs.
Objective:
To summarize recent literature on the biological activities of thiazole ring-containing compounds Methods: A literature survey regarding the topics from the year 2015 up to now was carried out. Older publications were not included, since they were previously analyzed in available peer reviews.
Results:
Nearly 124 research articles were found, critically analyzed, and arranged regarding the synthesis and biological activities of thiazoles derivatives in the last 5 years.
Related Concept Videos
Five-Membered Heterocyclic Aromatic Compounds: Overview
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Nomenclature of Aryl and Heterocyclic Amines
Aromatic Hydrocarbon Cations: Structural Overview
Removing one hydrogen from the intervening CH2 group with both...
Assembly of Signaling Complexes
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Antifungal Agents


