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A Red-Berry Mixture as a Nutraceutical: Detailed Composition and Neuronal Protective Effect
Noelia Carballeda-Sangiao1, Susana Chamorro1,2, Sonia de Pascual-Teresa1
1Departamento de Metabolismo y Nutrición, Instituto de Ciencia y Tecnología de Alimentos y Nutrición (ICTAN-CSIC), C/José Antonio Nováis, 10, 28040 Madrid, Spain.
Molecules (Basel, Switzerland)
|June 2, 2021
Summary
This study highlights a freeze-dried red berry blend rich in anthocyanins. The blend demonstrated neuroprotective effects by reducing oxidative stress in a cell model, suggesting nutraceutical potential.
Area of Science:
- Nutritional Science
- Neuroscience
- Pharmacology
Background:
- Dietary recommendations emphasize fruit and vegetable intake for health.
- Nutraceuticals offer an alternative for achieving optimal intake of beneficial compounds like polyphenols.
- A freeze-dried red berry mixture was investigated for its polyphenol content and neuroprotective properties.
Purpose of the Study:
- To characterize the polyphenol composition of a red berry mixture.
- To evaluate the neuroprotective potential of the berry blend in a cellular model of neurological damage.
- To assess the effect of berry polyphenols on cell viability and redox state.
Main Methods:
- Characterization of polyphenol composition, focusing on anthocyanins.
- Assay of the red berry blend in a differentiated SH-SY5Y cell model.
- Measurement of reactive oxygen species (ROS) formation and cell viability using flow cytometry.
Main Results:
- The red berry mixture was rich in anthocyanins, with a total content of 2.8 mg/g (cyanidin-3-glucoside equivalents).
- The berry extract inhibited ROS formation in differentiated SH-SY5Y cells by 33% at 250 µg/mL.
- The extract demonstrated potential for maintaining cell viability under conditions of neurological damage.
Conclusions:
- The characterized red berry blend possesses significant anthocyanin content.
- Berry-derived polyphenols exhibit inhibitory effects on oxidative stress in a neuronal cell model.
- This freeze-dried berry blend shows promise as a nutraceutical for preventing neurodegeneration.
