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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Antimicrobial drug resistance is a critical global health challenge.
  • Natural polymers like hyaluronic acid and spider silk offer biocompatible platforms for novel therapeutic materials.
  • Developing effective antimicrobial agents is essential for the biomedical industry.

Purpose of the Study:

  • To synthesize and characterize novel hybrid hydrogels from hyaluronic acid and spider silk.
  • To evaluate the physicochemical, mechanical, and biological properties of these hydrogels.
  • To explore their potential as antimicrobial agents and in drug delivery systems.

Main Methods:

  • Chemical crosslinking of hyaluronic acid and spider silk.
  • Physicochemical characterization using SEM, FTIR, and contact angle measurements.
  • Assessment of swelling, degradation, viscosity, conductivity, cytotoxicity, and antimicrobial activity.

Main Results:

  • Successfully synthesized crosslinked, porous, hydrophilic HA/Ss hydrogels.
  • Demonstrated excellent antimicrobial activity against gram-negative and gram-positive bacteria.
  • Exhibited low cytotoxicity towards human postnatal fibroblasts.
  • Hydrogels displayed shear-thinning behavior suitable for 3D printing.

Conclusions:

  • HA/Ss hydrogels are a promising alternative for overcoming antimicrobial resistance.
  • These hydrogels are suitable for external antimicrobial and anti-inflammatory drug delivery.
  • Their properties enable applications in 3D printing, such as antimicrobial surgical meshes.