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Rapid Progress in Immunotherapies for Multiple Myeloma: An Updated Comprehensive Review
1Department of Pathology, Keio University, School of Medicine, Tokyo 160-8582, Japan.
Cancers
|June 2, 2021
Summary
New immunotherapies, including antibody-drug conjugates and CAR-T cells targeting BCMA, offer hope for incurable multiple myeloma (MM). Research focuses on novel targets and combination approaches to improve durable responses and patient outcomes.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- Multiple myeloma (MM) treatments like PIs, IMiDs, and mAbs have limitations, with most patients relapsing and becoming refractory.
- Genetic heterogeneity and clonal evolution contribute to MM's incurability and treatment resistance.
- Novel therapeutic strategies are crucial for achieving deep, durable responses and improving MM patient outcomes.
Purpose of the Study:
- To provide a comprehensive review of recent clinical and preclinical advances in multiple myeloma therapy.
- To focus on BCMA-targeted immunotherapies and emerging novel targets in MM treatment.
- To discuss the future perspectives and potential treatment paradigm shifts in MM.
Main Methods:
- Review of current literature on multiple myeloma treatments.
- Analysis of clinical trial data for BCMA-targeted immunotherapies.
- Exploration of novel therapeutic targets and combination strategies.
Main Results:
- Belantamab mafodotin (an ADC targeting BCMA) was approved in 2020.
- Various immunotherapies are in development, including bispecific antibodies (BiTE), CAR-T cells, CAR-NK cells, and DC vaccines.
- Numerous clinical trials are ongoing or planned for novel MM therapies.
Conclusions:
- Despite advances, MM remains incurable, necessitating novel therapeutic approaches.
- BCMA-targeted therapies and other immunotherapies show promise for improving MM treatment.
- Combination therapies and allogeneic CAR-T/NK cell therapies may significantly alter the MM treatment landscape.
Keywords:
ADCBCMABiTEallogenic CAR-NK cellautologous CAR-T cellbelanatmab mafadotinbispecific antibodyimmunotherapiesmultiple myelomaMore Related Videos
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