Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

44
Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
44
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

13.0K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.0K
Myocarditis IV: Nursing Management01:22

Myocarditis IV: Nursing Management

72
Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
72

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Strategies to prevent ventilator-associated pneumonia in critically ill mechanically ventilated patients: a SIAARTI consensus statement.

Journal of anesthesia, analgesia and critical care·2026
Same author

Lung- and diaphragm-protective mechanical ventilation in acute respiratory distress syndrome.

Intensive care medicine·2026
Same author

Airway Occlusions to Measure Inspiratory Effort, Respiratory Drive, and Lung Mechanics During Noninvasive Ventilation.

American journal of respiratory and critical care medicine·2026
Same author

Personalized automatic management of tracheal cuff pressure and subglottic secretions drainage to prevent pneumonia in critically ill intubated patients. The MICROINHALO multicenter randomized controlled trial.

Intensive care medicine·2026
Same author

Impact of appropriate antimicrobial therapy on patient outcomes and antimicrobial use: a sub analysis of the DIANA Study Dataset.

Intensive care medicine·2026
Same author

Outcomes of critically ill patients with newly diagnosed Burkitt's lymphoma: a monocentric retrospective study.

Annals of intensive care·2026

Related Experiment Video

Updated: Nov 3, 2025

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

10.2K

Immune Modulation in Critically Ill Septic Patients.

Salvatore Lucio Cutuli1, Simone Carelli1, Domenico Luca Grieco1

  • 1Dipartimento di Scienze dell' Emergenza, Anestesiologiche e della Rianimazione, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Medicina (Kaunas, Lithuania)
|June 2, 2021
PubMed
Summary
This summary is machine-generated.

Sepsis treatment involves immune alteration. While pharmacological immune modulation risks patient outcomes, extracorporeal methods offer temporary inflammatory mediator removal, but their clinical role in sepsis needs more research.

Keywords:
blood purificationextracorporeal immune modulationinfectionrenal replacement therapysepsisseptic shock

More Related Videos

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness
09:17

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness

Published on: May 2, 2017

9.1K
A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
05:56

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

2.3K

Related Experiment Videos

Last Updated: Nov 3, 2025

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

10.2K
Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness
09:17

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness

Published on: May 2, 2017

9.1K
A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats
05:56

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

2.3K

Area of Science:

  • Critical care medicine
  • Immunology
  • Infectious diseases

Background:

  • Sepsis stems from infection-induced immune dysregulation.
  • Current immune-modulating therapies for sepsis include pharmacological and extracorporeal approaches.
  • Pharmacological methods may yield adverse long-term effects, potentially worsening patient outcomes.

Purpose of the Study:

  • To evaluate the current understanding and evidence for immune modulation in critically ill septic patients.
  • To highlight the limitations and uncertainties surrounding these therapies.
  • To advocate for further research into evidence-based, personalized approaches.

Main Methods:

  • Review of existing literature on pharmacological and extracorporeal immune modulation in sepsis.
  • Analysis of the clinical effects and evidence supporting these therapies.
  • Identification of knowledge gaps in sepsis management.

Main Results:

  • Extracorporeal immune modulation offers short-term removal of inflammatory mediators.
  • The overall role and efficacy of immune modulation in critically ill septic patients remain unclear.
  • Limited evidence currently supports the widespread use of these therapies in clinical practice.

Conclusions:

  • The clinical utility of immune modulation in sepsis requires further investigation.
  • An evidence-based and personalized approach is crucial for advancing sepsis management.
  • Future research should focus on clarifying the role and optimizing the application of immune-modulating therapies.