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On the in vitro cytotoxicity of 1-chloroethyl-2-chloromethyl-2-imidazoline hydrochloride
1Laboratory of Experimental Tumour Therapy, Medical Academy, Sofia.
Acta Physiologica Et Pharmacologica Bulgarica
|January 1, 1988
Abstract:
The cytotoxic activity of the monofunctional alkylating agent 1-chloroethyl-2-chloromethyl-2-imidazoline hydrochloride (chlorimidazine), synthesized according to predetermined properties, is characterized. The data obtained show that the substance has a cell-cycle state nonspecific cytotoxic effect. The interaction of chlorimidazine with cellular DNA is traced. It is found that the substance does not induce a break in the macromolecule, apurine sites or intercalation. Ensuing from the chemical structure of the compound, the probable mechanism of its cytotoxic action is discussed.