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Related Experiment Video

Updated: Nov 3, 2025

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
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Electroconvulsive Therapy Impact on Memory Performance in Patients With Depression.

Oscar Mauricio Castaño Ramírez1, Carlos Andrés Gómez Bedoya1, Rocío Lemos Buitrago1

  • 1Department of Mental Health and Human Behavior, University of Caldas, Manizales, Colombia.

Revista Colombiana De Psiquiatria (English Ed.)
|June 2, 2021
PubMed
Summary

Electroconvulsive therapy significantly improved depression symptoms without negatively impacting most memory functions. A slight decline in delayed recognition memory was observed, particularly in patients with lower education and bitemporal electrode placement.

Keywords:
DepresiónElectroconvulsive therapy (ECT)MemoriaMemoryNeuropsychological testing DepressionPruebas neuropsicológicasTerapia electroconvulsiva (TEC)

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Electroconvulsive therapy (ECT) safety has improved, with cognitive effects, particularly memory, being a primary concern.
  • Negative public and professional perceptions of ECT in Colombia may stem from limited information.
  • Understanding ECT's impact on memory is crucial for informed clinical decisions and patient care.

Purpose of the Study:

  • To evaluate changes in memory and depressive symptom severity in patients undergoing ECT.
  • To investigate the cognitive effects of ECT in a Colombian cohort with severe depression.

Main Methods:

  • Twenty-three patients (23-70 years) with severe depression received ECT.
  • Memory was assessed using the Rey Auditory Verbal Learning Test (RAVLT).
  • Depressive symptoms were measured with the Hamilton Depression Scale (HAMD) pre-ECT and post-ECT.

Main Results:

  • ECT led to significant improvements in depression ratings.
  • No significant changes were observed in RAVLT learning trials or delayed recall.
  • A significant decrease in delayed recognition memory was noted post-ECT.

Conclusions:

  • Cognitive assessment before and after ECT is a practical and valuable procedure.
  • ECT generally does not worsen memory performance in patients with depression.
  • Delayed recognition memory may be affected by ECT, especially in individuals with lower education and bitemporal electrode placement.