Data-driven gait analysis for diagnosis and severity rating of Parkinson's disease

Parkinsons disease (PD) is the second most neurodegenerative disease, which results in gradual loss of movements. To diagnose PD in a clinical setting, clinicians generally use clinical manifestations like motor and non-motor symptoms and rate the severity based on unified Parkinsons disease rating scale (UPDRS). Such clinical assessment largely depends on the expertise and experience of the clinicians and it is subjective leading to variation in assessment between clinicians. As the gait of people with Parkinson's generally differs from gait of healthy age-matched adults, the assessment of gait abnormalities can lead to not only the diagnosis of PD but also the rating of severity level based on motor symptoms. Hence, in this paper, a data-driven gait classification framework using the supervised machine learning algorithms is presented. Using the publicly available gait datasets acquired using vertical ground reaction force (VGRF) sensors, we present a correlation based feature extraction technique for improved stage classification of PD. Significant biomarkers from spatiotemporal gait features are obtained based on the correlation, and the normal distribution of the gait dataset is assessed using the Shapiro-Wilk test. Subsequently, four supervised machine learning algorithms, namely, K-nearest neighbours (KNN), Naive Bayes (NB), Ensemble classifier (EC) and Support vector machine (SVM) are used to rate the severity level of PD according to the Hoehn and Yahr (H&Y) scale. The performance of the classifiers, assessed using the confusion matrix and parallel coordinate plots, highlights that SVM can result in a classification accuracy of 98.4%. Moreover, with minimal gait feature set acquired based on the rank correlation, the proposed approach outperforms several other state-of-the-art methods that have used the same dataset for PD stage classification.