Related Experiment Video

Updated: Nov 3, 2025

A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

24.4K

The association between hepatitis C virus infection and renal function

Gantsetseg Gantumur1,2, Batbold Batsaikhan3, Ching-I Huang1,4

  • 1Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC.

Journal of the Chinese Medical Association : JCMA
|June 2, 2021
PubMed

Insights

Hepatitis C virus (HCV) infection is linked to decreased kidney function, particularly in patients who are obese, diabetic, or hypertensive. This study clarifies the association between HCV and chronic kidney disease (CKD).

Area of Science:

  • Nephrology
  • Hepatology
  • Epidemiology

Background:

  • The relationship between Hepatitis C Virus (HCV) infection and Chronic Kidney Disease (CKD) remains debated.
  • Investigating the impact of HCV on renal function is crucial for understanding disease progression.

Purpose of the Study:

  • To determine if HCV infection significantly affects kidney function.
  • To analyze the association between clinical factors of chronic hepatitis C (CHC) and reduced glomerular filtration rate (eGFR).

Main Methods:

  • A cohort study involving 3360 patients with HCV infection and 3360 matched controls (2004-2016).
  • Estimated glomerular filtration rate (eGFR) calculated using the Modification of Diet in Renal Diseases formula.
  • Demographic and laboratory data analyzed using multivariate logistic regression.

Main Results:

  • HCV-infected patients showed a significantly lower eGFR compared to controls.
  • Obesity (BMI >25 kg/m2), hypertension, and diabetes were independently associated with low eGFR in controls.
  • These conditions (obesity, hypertension, diabetes) showed an interaction with HCV infection in reducing eGFR.

Conclusions:

  • HCV infection is associated with decreased kidney function (low eGFR).
  • This association is particularly evident in patients with co-existing obesity, diabetes, or hypertension.
  • Findings highlight the importance of managing these comorbidities in HCV patients to preserve renal health.
Abstract

More Related Videos

Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection04:11

Author Spotlight: Advancements and Challenges in Hepatitis B Virus Detection

Published on: December 15, 2023

4.0K
Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells09:02

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

7.6K

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
44
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
50
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
232
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
167
Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug01:14

Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug

In pharmacotherapy, monitoring drug concentrations is paramount, especially for drugs whose therapeutic effects hinge on both the active compound and its metabolite. Hepatic impairment profoundly influences drug potency by altering liver function. If the drug is more potent than its metabolite, impaired liver function amplifies drug activity due to elevated drug concentration levels. Conversely, if the metabolite holds greater potency, diminished liver function diminishes drug activity by...
52
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
230