Related Experiment Video
Updated: Nov 3, 2025
07:54
Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
20.1K
Predictors of obstructive sleep apnea misclassification when using total bed time versus total sleep time
Wei Yang Lim1, Kay Choong See2
1Division of Respiratory & Critical Care Medicine, Department of Medicine, National University Hospital, Singapore, Singapore. wei_yang_lim@nuhs.edu.sg.
Scientific Reports
|June 2, 2021
Summary
Using total bed time instead of total sleep time can misclassify obstructive sleep apnea (OSA) severity. Older age and lower BMI increase this risk, potentially leading to underdiagnosis of OSA.
Area of Science:
- Sleep Medicine
- Respiratory Medicine
- Diagnostic Accuracy
Background:
- Obstructive sleep apnea (OSA) is a widespread condition with serious health implications.
- Home sleep apnea tests are common for OSA diagnosis, but methodology may affect accuracy.
- Accurate OSA severity assessment is crucial for effective treatment and patient outcomes.
Purpose of the Study:
- To determine the frequency of OSA misclassification when using total bed time versus total sleep time.
- To identify predictors of OSA misclassification in patients undergoing sleep studies.
Main Methods:
- Retrospective observational study of 1621 patients from a tertiary hospital sleep laboratory.
- Misclassification defined as less severe OSA using total bed time compared to total sleep time.
- Logistic regression analysis to identify predictors of misclassification.
Main Results:
- 18.5% of patients (300/1621) were misclassified.
- Age (OR 1.02) and BMI (OR 0.97) were significant predictors of misclassification.
- Significant risk of misclassification observed in patients aged ≥57 years with BMI < 32.3 kg/m².
Conclusions:
- Total bed time may underestimate OSA severity, leading to misclassification.
- Older age and lower BMI are key risk factors for this diagnostic error.
- Clinical guidelines should consider these factors to ensure accurate OSA diagnosis and management.
Related Concept Videos
01:21Sleep Apnea
267
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
267
02:07Blind Procedures
12.4K
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
12.4K
01:24Substance Use Disorders Affecting Sleep
253
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
253
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
179
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
179
01:24Sleep-Wake Cycles
2.0K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
2.0K
01:13Insufficient Sleep and Sleep Deprivation
411
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
411