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Related Experiment Video

Updated: Nov 3, 2025

Trichuris muris Infection: A Model of Type 2 Immunity and Inflammation in the Gut
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Trichuris muris Infection: A Model of Type 2 Immunity and Inflammation in the Gut

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The interplay between Trichuris and the microbiota.

Melissa A E Lawson1,2,3,4, Ian S Roberts1,3,4, Richard K Grencis1,2,3,4

  • 1Lydia Becker Institute for Immunology and Inflammation, Manchester, M13 9PT, UK.

Parasitology
|June 2, 2021
PubMed
Summary

Gut bacteria are essential for whipworm (Trichuris) survival and infection. These microbes interact with worms and the host immune system, influencing parasitic worm persistence.

Keywords:
Germ-free miceTrichuris murismicrobial diversity hypothesismicrobiota

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Area of Science:

  • Parasitology
  • Microbiology
  • Immunology

Background:

  • Intestine-dwelling helminths are common human pathogens.
  • Helminths manipulate host immune responses for survival.
  • Gut microbiota and parasite-specific microbes play a crucial role in helminth persistence.

Purpose of the Study:

  • To investigate the role of gut bacteria in helminth infections.
  • To understand the interactions between worms, host immunity, and gut microbiota.
  • To explore the communication mechanisms between hosts, microbes, and parasites.

Main Methods:

  • Utilized various mouse models, including laboratory, germ-free, and rewilded mice.
  • Investigated the necessity of bacteria for Trichuris (whipworm) hatching and infection.
  • Analyzed the Trichuris-specific gut microbiota.
  • Examined the role of microbial metabolites like butyrate in host-microbe-parasite communication.

Main Results:

  • Trichuris requires bacteria to hatch and infect the host.
  • Trichuris harbors a specific gut microbiota.
  • Metabolites such as butyrate mediate communication and regulate immune responses.
  • Gut bacteria significantly influence worm infections.

Conclusions:

  • Gut bacteria are critical for the life cycle and persistence of parasitic worms like Trichuris.
  • The host, gut microbiota, and parasite engage in complex metabolic and immune interactions.
  • This research establishes an emerging field in whipworm parasitology focused on microbial contributions to infection.