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Author Spotlight: Deciphering Coagulation Disorders in Traumatic Brain Injury Patients
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Is the mechanism of COVID-19 coagulopathy still a rabbit's hole?

Ashna Rajan1, Ganesh Keshav Thirunavukkarasu2, Richard F Lockey3

  • 1Division of Geriatrics Medicine, Brown University Alpert School of Medicine, Providence, RI, 02903, USA.

Journal of Cell Communication and Signaling
|June 2, 2021
PubMed

Insights

The severity of COVID-19 is linked to blood clotting issues (coagulopathy). SARS-CoV-2 impacts key regulatory pathways, including the complement pathway, offering targets for new therapies.

Area of Science:

  • * Pathophysiology and immunology
  • * Coagulation and thrombosis
  • * Infectious disease mechanisms

Background:

  • * The severity of coronavirus disease 2019 (COVID-19) is complex and often associated with coagulopathy.
  • * The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) virus interacts with critical host regulatory systems.
  • * Understanding these interactions is crucial for managing severe COVID-19 cases.

Purpose of the Study:

  • * To elucidate the role of coagulopathy in COVID-19 pathophysiology.
  • * To examine the specific regulatory pathways affected by SARS-CoV-2.
  • * To identify potential therapeutic targets for future treatments.

Main Methods:

  • * Review of current literature on COVID-19 pathophysiology.
  • * Analysis of the impact of SARS-CoV-2 on the renin-angiotensin system.
  • * Investigation of the von Willebrand Factor's role in COVID-19-associated coagulopathy.
  • * Detailed examination of the complement pathway's involvement.

Main Results:

  • * Coagulopathy is a significant determinant of COVID-19 severity.
  • * SARS-CoV-2 directly or indirectly affects the renin-angiotensin system and von Willebrand Factor.
  • * The complement pathway is a critical mediator in the inflammatory and thrombotic responses to SARS-CoV-2 infection.

Conclusions:

  • * Targeting coagulopathy-related pathways may mitigate COVID-19 severity.
  • * The renin-angiotensin system, von Willebrand Factor, and complement pathway are key areas for therapeutic intervention.
  • * Further research into these pathways can guide the development of novel COVID-19 treatments.
Keywords:
ACE2COVID-19CoagulopathyComplementSARS-CoV2Thromboinflammation

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