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Fengycin A Analogues with Enhanced Chemical Stability and Antifungal Properties
Diana Gimenez1, Aoife Phelan2, Cormac D Murphy2
1Department of Chemistry, Durham University, South Road, Durham DH1 3LE, United Kingdom.
Abstract:
Fengycins are cyclic lipo-depsipeptides produced by Bacillus spp. that display potent antifungal properties but are chemically unstable. This instability has meant that no total synthesis of any fengycin has been published. Here we report the synthesis of fengycin A analogues that display enhanced antifungal properties and chemical stability under both basic and acidic conditions. The analogues prepared also demonstrate that the fengycin core structure can be modified and simplified without the loss of antifungal activity.
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