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Changes in vasopressin and cortisol secretion during operant drinking in dehydrated pigs
R F Parrott1, S N Thornton, B A Baldwin
1Institute of Animal Physiology and Genetics Research, Agricultural and Food Research Council, Babraham, Cambridge, United Kingdom.
The American Journal of Physiology
|August 1, 1988
Summary
Dehydrated pigs rapidly rehydrated, normalizing osmolality and lysine vasopressin (LVP) levels. Oropharyngeal factors inhibiting LVP release were masked by fast gut water absorption during normal drinking.
Area of Science:
- Physiology
- Endocrinology
- Animal Science
Background:
- Dehydration triggers hormonal responses to restore fluid balance.
- Understanding the regulation of vasopressin is crucial for fluid homeostasis.
Purpose of the Study:
- To investigate endocrine changes during rehydration in dehydrated pigs.
- To explore the role of oropharyngeal factors in vasopressin release during fluid intake.
Main Methods:
- Two experiments involving 24-h dehydrated pigs consuming water or isotonic saline.
- Measurements included water/fluid intake, osmolality, hematocrit, and plasma lysine vasopressin (LVP) and cortisol.
Main Results:
- Dehydration-induced increases in osmolality and LVP were rapidly reversed during water rehydration.
- Plasma LVP levels declined abruptly during saline ingestion, despite elevated osmolality.
- Cortisol levels were unaffected by dehydration but decreased during rehydration.
Conclusions:
- Rapid gut water absorption in pigs may obscure oropharyngeal inhibitory signals on vasopressin release during normal rehydration.
- Oropharyngeal factors play a role in modulating vasopressin release, but their effect is influenced by absorption rates.