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Updated: Nov 3, 2025

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates
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Prescribing Silver Chirality with DNA Origami.

Yinan Zhang1,2, Zhi-Bei Qu1, Chu Jiang3

  • 1School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.

Journal of the American Chemical Society
|June 3, 2021
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Summary
This summary is machine-generated.

Researchers developed a DNA origami method to create 3D chiral silver nanostructures. This technique enables precise control over chirality and morphology for tailored optical properties.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biotechnology

Background:

  • Chiral metal nanostructures exhibit tunable optical activity through surface plasmon resonances.
  • Precise bottom-up fabrication of arbitrary chiral nanostructures remains a significant synthetic challenge.

Purpose of the Study:

  • To develop a DNA origami-enabled strategy for synthesizing 3D chiral silver nanostructures with controlled morphology and chirality.
  • To investigate the mechanism of silver precursor enrichment and nucleation on DNA origami scaffolds.
  • To demonstrate the tailorable plasmonic optical activity of the fabricated nanostructures.

Main Methods:

  • Utilized DNA origami scaffolds with specifically designed single-stranded protruding clustered DNA (pcDNA).
  • Employed an aqueous solution metallization strategy involving diamine silver(I) complexes.
  • Investigated synergistic interactions (coordination, hydrogen bonds, ion-π) between silver complexes and DNA bases.
  • Fabricated helical silver patterns using tubular DNA origami structures.

Main Results:

  • Achieved site-specific pcDNA condensation and silver precursor enrichment on DNA origami.
  • Successfully synthesized helical silver patterns up to micrometer length with well-defined chirality and pitches.
  • Demonstrated tailorable plasmonic optical activity in the metallized chiral silver nanostructures.

Conclusions:

  • The DNA origami-enabled metallization strategy provides a novel route for synthesizing programmable inorganic materials with arbitrary morphology and chirality.
  • This method overcomes previous synthetic challenges in fabricating complex chiral nanostructures.
  • Opens new avenues for designing materials with specific optical properties for advanced applications.