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  3. Programming Dimensional Transitions In Dna Brick Crystals Via Interfacial Connectivity.
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  3. Programming Dimensional Transitions In Dna Brick Crystals Via Interfacial Connectivity.

Related Experiment Video

Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

Programming Dimensional Transitions in DNA Brick Crystals via Interfacial Connectivity.

Xin Huang1, Yue Wang1, Wenhe Ma1

  • 1State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, New Cornerstone Science Laboratory, Frontiers Science Center for Transformative Molecules, Zhang Jiang Institute for Advanced Study and National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, China.

Angewandte Chemie (International Ed. in English)
|June 18, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Researchers developed a programmable method to control DNA crystal assembly. By adjusting interface connections, they precisely engineered the transition from 1D to 2D structures and their widths.

Keywords:
DNA bricksdimensional transitioninterfacial connectivitymolecular self‐assemblynanoribbon arrays

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Biotechnology

Background:

  • Precise control over molecular self-assembly dimensionality and macroscopic structures is a significant challenge.
  • DNA nanotechnology offers a versatile platform for creating complex nanoscale architectures.

Purpose of the Study:

  • To introduce a programmable strategy for controlling the dimensional transition (1D to 2D) and structural width of DNA brick crystals.
  • To establish interfacial connectivity as a predictable parameter for engineering self-assembled nanostructures.

Main Methods:

  • Engineering DNA brick crystal interfaces by varying the number of connecting strands (Nx).
  • Utilizing quantitative design parameters (Nx) to analyze dimensional transitions.
  • Employing thermal and thermodynamic analyses to understand the stability of assembled structures.

Main Results:

  • A sharp dimensional threshold (Nx=8 to Nx=12) was identified for the 1D-to-2D transition, independent of lattice type (honeycomb, square).
  • Below Nx=8, assemblies form 1D nanoribbons; above Nx=12, 2D arrays form with widths increasing monotonically with Nx.
  • The threshold behavior is attributed to size-dependent thermal stability of laterally connected domains.

Conclusions:

  • Interfacial connectivity serves as a predictive handle for on-demand engineering of self-assembled nanostructures.
  • Programmable control over dimensionality and structural width is achievable through interface engineering.
  • This strategy enables the precise fabrication of nanostructures with desired dimensions and widths.