Small-fibre polyneuropathy caused by chemical agent resistant coating

Area of Science:

• Toxicology
• Neurology
• Occupational Health

Background:

• Chemical Agent Resistant Coating (CARC) is utilized in military applications for durable, protective finishes on vehicles and equipment.
• Occupational exposure to industrial chemicals can lead to various adverse health effects, including neurological disorders.
• Peripheral neuropathies, particularly small-fibre polyneuropathy (SFP), can manifest from toxic exposures.

Observation:

• A 65-year-old male military service member experienced acute, severe burning pain in his hands and feet following CARC fume exposure.
• Symptoms persisted for over three decades, indicating a chronic condition.

Findings:

• Standard laboratory tests for peripheral neuropathies were inconclusive.
• Nerve conduction studies revealed an axonal-loss polyneuropathy.
• Skin biopsy confirmed a diagnosis of small-fiber polyneuropathy (SFP).

Implications:

• This case represents the first documented instance of SFP resulting from acute CARC exposure.
• Findings suggest a need for increased awareness and preventative measures regarding CARC exposure in occupational settings.
• Long-term surveillance is crucial for understanding the chronic effects of chemical exposures.