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Updated: Jul 23, 2026
12:31
A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay
Published on: February 28, 2015
Detection of biotinylated nucleic acid hybrids by antibody-coated gold colloid
S Tomlinson1, A Lyga, E Huguenel
1Molecular Diagnostics Inc., Miles Research Center, West Haven, Connecticut 06516.
Analytical Biochemistry
|May 15, 1988
Abstract:
A simple and sensitive nonradioactive method for detecting biotinylated nucleic acid hybrids on nitrocellulose paper is described. The method employs anti-biotin antibody-coated gold colloid and silver enhancement. Comparative results indicate sensitivity similar to that of a commonly used enzymatic colorimetric detection method.
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