Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Single-Strand DNA Binding Proteins01:03

Single-Strand DNA Binding Proteins

15.7K
For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
15.7K
Proofreading01:31

Proofreading

7.3K
Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore,  it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
Errors During Replication are Corrected by the DNA Polymerase...
7.3K
Proofreading01:43

Proofreading

57.6K
Overview
57.6K
DNA Base Pairing02:27

DNA Base Pairing

30.9K
Erwin Chargaff’s rules on DNA equivalence paved the way for the discovery of base pairing in DNA. Chargaff’s rules state that in a double-stranded DNA molecule,
30.9K
DNA Base Pairing02:27

DNA Base Pairing

30.6K
30.6K
Mismatch Repair01:36

Mismatch Repair

41.7K
Overview
41.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Study of electroreflectance spectrum and Franz-Keldysh effect at metal-GaAs interfaces].

Guang pu xue yu guang pu fen xi = Guang pu·2008
Same author

[Study on electro-degradation of new conjugated polymer PFO-BT15 light emitting diodes].

Guang pu xue yu guang pu fen xi = Guang pu·2008
Same author

Comparison of the curative effects of video assisted thoracoscopic anterior correction and small incision, thoracotomic anterior correction for idiopathic thoracic scoliosis.

Chinese medical journal·2008
Same author

Distribution and sources of mercury in soils from former industrialized urban areas of Beijing, China.

Environmental monitoring and assessment·2008
Same author

[Main flavonoids from Sophora flavescenes].

Yao xue xue bao = Acta pharmaceutica Sinica·2008
Same author

External validation and prediction employing the predictive squared correlation coefficient test set activity mean vs training set activity mean.

Journal of chemical information and modeling·2008
Same journal

Enhancing cereal productivity via nitrogen use efficiency: from conventional breeding to modern genomics.

Frontiers in genetics·2026
Same journal

Transcriptomic analysis reveals FcγR-mediated phagocytosis as a key pathway for the anti-inflammatory action of <i>Polygonatum sibiricum</i> polysaccharides in loach.

Frontiers in genetics·2026
Same journal

A novel <i>ABO</i> splice site variant underlying the A<sub>3</sub> phenotype: immunogenetic basis and functional dissection.

Frontiers in genetics·2026
Same journal

Case Report: Identification of two novel <i>ALMS1</i> variants in a patient with a ciliopathy resembling Alström syndrome.

Frontiers in genetics·2026
Same journal

Integrative analysis identifies Hspa5 as a key regulator of the ERS/UPR-immune axis in spinal cord injury.

Frontiers in genetics·2026
Same journal

Evaluation of genomic selection to improve survival of eastern oysters infected with <i>Perkinsus marinus</i>.

Frontiers in genetics·2026
See all related articles

Related Experiment Video

Updated: Nov 3, 2025

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

11.9K

Stable DNA Sequence Over Close-Ending and Pairing Sequences Constraint.

Xue Li1, Ziqi Wei2, Bin Wang1

  • 1The Key Laboratory of Advanced Design and Intelligent Computing, Ministry of Education, School of Software Engineering, Dalian University, Dalian, China.

Frontiers in Genetics
|June 3, 2021
PubMed
Summary
This summary is machine-generated.

This study introduces an Improved Chaos Whale (ICW) optimization algorithm to design DNA sequences for DNA computing. The new method enhances sequence stability and accuracy, overcoming limitations of previous approaches.

Keywords:
DNA computingDNA sequence designICWWOAconstraint

More Related Videos

Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

7.2K
Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

20.8K

Related Experiment Videos

Last Updated: Nov 3, 2025

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
10:23

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

11.9K
Design and Synthesis of a Reconfigurable DNA Accordion Rack
07:44

Design and Synthesis of a Reconfigurable DNA Accordion Rack

Published on: August 15, 2018

7.2K
Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

20.8K

Area of Science:

  • Biotechnology
  • Computational Biology
  • Molecular Computing

Background:

  • DNA computing utilizes molecular biotechnology for complex problem-solving.
  • Designing DNA sequences is a multi-objective optimization challenge.
  • Previous methods suffered from sequence self-reaction, reducing accuracy.

Purpose of the Study:

  • To optimize DNA sequence design for enhanced DNA computing.
  • To address sequence self-reaction and improve molecular hybridization efficiency.
  • To develop stable and usable DNA sequence sets.

Main Methods:

  • Proposed Pairing Sequences Constraint (PSC) and Close-ending constraints.
  • Introduced the Improved Chaos Whale (ICW) optimization algorithm.
  • Integrated a predator-prey strategy and chaos-based sine/cosine functions into ICW.

Main Results:

  • The ICW algorithm outperformed other methods on benchmark functions.
  • Achieved minimum values for one-third of benchmark functions.
  • Generated DNA sequences with minimal fitness values and stable structures.

Conclusions:

  • The proposed constraints and ICW algorithm effectively optimize DNA sequence design.
  • The new method enhances the stability and usability of DNA sequences for computing.
  • This approach improves the accuracy and efficiency of DNA computing applications.