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Updated: Nov 3, 2025

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis
Published on: December 8, 2023
Eltrombopag post autologous hematopoietic stem cell transplant - an emerging indication in younger pediatric patients
Aditya Kumar Gupta1, Prasanth Srinivasan1, Gargi Das1
1Division of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences New Delhi 110029, India.
Background:
Engraftment of neutrophils and platelets after hematopoietic stem cell transplant (HSCT) is imperative for optimal outcomes. Eltrombopag has been used in adults after HSCT to boost platelet production. Its use in pediatric post HSCT patients has been limited.
Methods:
The clinical and laboratory details of a post autologous HSCT patient were fetched by a retrospective review of the records.
Results:
A 5-year old male child had primary thrombocytopenia post autologous HSCT for refractory Hodgkin lymphoma. Although the stem cell dose infused was adequate, the child had a delay in the engraftment of platelets. After ruling out the causes of post HSCT thrombocytopenia, eltrombopag was started for the child. With the use of eltrombopag, normal thrombopoiesis was restored in the child.
Conclusion:
Eltrombopag was effective and safe in overcoming post-HSCT primary thrombocytopenia in our patient.
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