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Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
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Hippo Signaling Pathway in Pancreas Development.
Yifan Wu1,2, Pauline Aegerter1, Michael Nipper1
1Department of Cell Systems and Anatomy, The University of Texas Health San Antonio, San Antonio, TX, United States.
Frontiers in Cell and Developmental Biology
|June 3, 2021
Summary
The Hippo signaling pathway regulates pancreatic development and cell plasticity. This review explores its role in cell differentiation, organ architecture, and crosstalk with other signaling pathways.
Area of Science:
- Developmental Biology
- Cell Signaling
- Pancreatic Biology
Background:
- The Hippo signaling pathway is crucial for pancreatic development and homeostasis.
- It controls cell fate, morphogenesis, and cellular plasticity in the adult pancreas.
- Loss-of-function studies reveal its role in progenitor cell balance and differentiation.
Purpose of the Study:
- To review recent findings on Hippo pathway functions in pancreatic development.
- To elucidate the mechanisms by which Hippo signaling governs cell differentiation and pancreatic architecture.
- To explore the crosstalk between Hippo signaling and other key pathways like NOTCH and WNT.
Main Methods:
- Review of existing loss-of-function research.
- Analysis of studies on YAP, a downstream effector of the Hippo pathway.
- Examination of Hippo signaling's role in pancreatic morphogenesis and cell polarization.
Main Results:
- Hippo signaling maintains progenitor cell balance and differentiation during organogenesis.
- YAP overactivation promotes ductal development and suppresses endocrine cell fate.
- Disruptions lead to acinar cell de-differentiation and pancreatitis-like phenotypes.
Conclusions:
- The Hippo pathway is essential for pancreatic development, cell differentiation, and tissue architecture.
- Understanding its mechanisms and crosstalk with other pathways is critical for pancreatic biology.
- Further research is needed to fully elucidate Hippo's governance of pancreatic cell fate and structure.
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