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Different Appearances of 3 Malignancies in 68Ga-PSMA-11 Versus 18F-FDG PET/CT
Friedrich Weitzer1, Tina Nazerani-Hooshmand, Reingard Maria Aigner
1From the Division of Nuclear Medicine, Department of Radiology, Medical University of Graz, Graz, Austria.
Abstract:
Prostate-specific membrane antigen (PSMA) overexpression has been described in various malignancies. Hereby we present a case of a 69-year-old man simultaneously diagnosed with prostate cancer, esophageal adenocarcinoma, and HCC (hepatocellular carcinoma). 18F-FDG PET/CT showed pathological uptake in the esophageal adenocarcinoma and the primary prostate tumor, whereas 68Ga-PSMA-11 PET/CT performed for staging of the histopathologically confirmed prostate cancer revealed the primary tumor and significant uptake in the HCC. This finding is remarkable because the high physiological liver uptake of 68Ga-PSMA-11 may hamper the detection of small lesions.
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