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Integration of titanium implants in irradiated bone. Histologic and clinical study
M Jacobsson1, A Tjellström, P Thomsen
1Ear, Nose and Throat Clinic, Sahlgren's Hospital, Göteborg, Sweden.
The Annals of Otology, Rhinology, and Laryngology
|July 1, 1988
Summary
Titanium implants show high success rates in bone tissue following radiation therapy for malignant tumors. Osseointegration is generally favorable, even years after treatment, indicating good implant stability.
Area of Science:
- Oncology
- Biomaterials Science
- Orthopedic Surgery
Background:
- Malignant tumors often require combined surgical and radiologic treatment.
- Radiation therapy can impact bone healing and osseointegration of implants.
- Skin-penetrating titanium implants are used in bone reconstruction.
Purpose of the Study:
- To evaluate the success of skin-penetrating titanium implants in irradiated bone.
- To assess osseointegration and implant survival rates in patients treated for malignant tumors.
- To determine the influence of time and radiation dose on implant outcomes.
Main Methods:
- Retrospective analysis of nine patients with malignant tumors.
- Insertion of titanium implants in irradiated bone at varying intervals post-treatment.
- Dosimetry assessment using the cumulative radiation effect formula.
- Follow-up evaluation of osseointegration and implant survival.
Main Results:
- 35 titanium fixtures were installed in total.
- Only five fixtures (14.3%) were lost due to lack of osseointegration.
- Follow-up ranged from 15 to 44 months.
- Implants were placed between 9 months and 37 years after irradiation.
Conclusions:
- Skin-penetrating titanium implants demonstrate a high success rate in irradiated bone.
- Osseointegration is achievable even long after radiation therapy for malignant tumors.
- These findings support the use of titanium implants in complex oncologic reconstructions.