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The Impact of Chromium Supplementation on Blood Pressure: A Systematic Review and Dose-Response Meta‑Analysis of

Abolfazl Lari1, Somaye Fatahi1, Mohammad Hassan Sohouli2,3

  • 1Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Shahid Hemmat Highway, Tehran, Iran.

High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension
|June 3, 2021
PubMed

Insights

Chromium supplementation significantly lowers blood pressure, reducing both systolic and diastolic measures. Specific forms like chromium yeast and brewer's yeast showed greater effects on systolic blood pressure.

Area of Science:

  • Nutritional Science
  • Cardiovascular Health
  • Evidence-Based Medicine

Background:

  • Conflicting results exist regarding chromium supplementation's effect on blood pressure.
  • Previous interventional studies show varied outcomes on blood pressure management.

Purpose of the Study:

  • To conduct a systematic review and meta-analysis on chromium supplementation's impact on blood pressure.
  • To synthesize evidence from randomized clinical trials (RCTs) on chromium and blood pressure.

Main Methods:

  • Systematic search of five databases (Web of Science, Scopus, Embase, Google Scholar, PubMed) up to March 2020.
  • Inclusion of 11 randomized clinical trials (RCTs) involving 637 participants.
  • Meta-analysis of RCTs assessing chromium's effect on systolic blood pressure (SBP) and diastolic blood pressure (DBP).

Main Results:

  • Chromium supplementation significantly reduced both SBP (WMD -2.51 mmHg) and DBP (WMD -1.04 mmHg).
  • Subgroup analysis indicated greater SBP reduction with chromium yeast and brewer's yeast.
  • Significant SBP reduction was observed in diabetic patients with chronic heart disease (CHD); dosage influenced SBP changes.

Conclusions:

  • Chromium supplementation effectively decreases both systolic and diastolic blood pressure.
  • Chromium yeast and brewer's yeast forms appear more effective for SBP reduction.
  • Further large-scale RCTs are recommended to validate these findings on blood pressure management.
Abstract

Keywords:
Blood pressureChromiumHypertensionMeta-analysis

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